Alicia, Brice, and Caroline are the ABCs—three close friends who have been brought together while working at the cozy medical practice of Drs. Markowitz and Strub in Midburg, Ohio. But when Alicia and Dr. Strub begin an affair, a dramatic chain of events ensues that gradually but drastically changes the office environment—ultimately requiring all five coworkers to redefine their relationships to one another. Finally, a questionable business venture precipitates a tragedy that will either tear them apart or bring them closer together.