Four graduates from a small Massachusetts college move to New York to make their way, they're broke, adrift, and buoyed only by their friendship and ambition. There is kind, handsome Willem, an aspiring actor; JB, a quick-witted, sometimes cruel Brooklyn-born painter seeking entry to the art world; Malcolm, a frustrated architect at a prominent firm; and withdrawn, brilliant, enigmatic Jude, who serves as their centre of gravity.
Over many decades, their complex relationships come to be defined by their respective addictions, successes, and traumas, in this immensely powerful novel of love and the limits of human endurance.